Psyched Wellness Releases Positive Amanita Mushroom Study

May 3, 2023 · Green Market Report

OLYMPUS DIGITAL CAMERA

The study showed how mushroom extracts could boost immune cells in the brain.

Psyched Wellness Ltd. (CSE: PSYC) (OTCQB: PSYCF) stock jumped 11% to lately sell at four cents based on the release of a new study demonstrating how mushroom extract can help modulate brain health.

The study, to be published in Frontiers in Pharmacology, shows that Amanita muscaria extract activates human microglia, which play a key role in maintaining brain function.

These mushrooms are known to contain muscarine, muscimol, muscazone, and ibotenic acid and have been used as an inebriant in eastern Siberia for centuries. The report said the chemical composition of these mushroom extracts is poorly characterized but likely contains many other compounds that could have effects on brain cells.

The effect of A. muscaria on brain tissue and cells is unknown.

The study, “Amanita muscaria extract potentiates production of proinflammatory cytokines by dsRNA-activated human microglia,” was conducted by the National Research Council of Canada (NRC). It demonstrates that Amanita muscaria extract activates immune cells of the brain called microglia, which are resident macrophage cells that act as the first and main form of active immunity in the central nervous system.

“The National Research Council of Canada based its research on our company’s proprietary Amanita Muscaria extract, AME-1, and proved additional benefits of our effective supplement. This is another key finding of function and furthers our understanding of the effects of AME-1,” says David Shisel, chief operations officer for Psyched Wellness.

Using human microglia cells grown in lab cultures, the group showed for the first time that Amanita muscaria activates these important brain immune cells to produce immune mediators, which can mobilize other immune cells in the brain and alter the way in which neurons function.

Microglia cells are involved in brain maintenance, clearing the central nervous system of plaques, damaged neurons, excess synapses, and infectious agents. Key areas of neuroinflammation and immune-induced changes in the brain may be responsible for migraines, depression, and changes in sleep patterns.

“The importance of this publication indicates for the first time that, under in vitro conditions, Amanita muscaria extract activates human microglia, which are immune cells in the brain. They are known as resident macrophages that act as the first and main form of the active immune defense system in the central nervous system,” said Brian Tancowny, scientific advisor for Psyched Wellness.

This study shows how Amanita muscaria extract can positively modulate brain health. At the same time, Amanita muscaria extract can cause microglia to express important receptors on their surface that can help them interact with other brain cells.

Using metabolite screening technology, the group also showed that Amanita muscaria extracts contain important metabolites such as trehalose, a sugar produced by some fungi and yeasts that is used as an ingredient in food, beauty products, and some pharmaceutical products. These metabolites could be playing an important role in mediating the microglial inflammatory responses.

Frontiers in Pharmacology is the 3rd most-cited and 6th largest research publisher and open science platform. Its research journals are community-driven and peer-reviewed by editorial boards of more than 202,000 top researchers. (Full Story)

Next Post

Cannabis Research for Veterans Bill Potentially Dead After Senate Rejection

Following the Senate’s rejection of a bill last week to require the Department of Veterans Affairs to conduct a study of veterans who use medical cannabis, Sen. John Tester (D-MT), chairman of the Senate Veterans Affairs Committee, told Military.com that the measure,…
Read
Previous Post

The Future of Cannabis is Latin and South America - Here Is How It Will Help Their Economies

Cannabis has been controversial for many years, but recently it has emerged as a potential solution for the struggling economies of Latin America. The region has been hit hard by various economic and political challenges, and cannabis may offer a…
Read
Random Post

Fetterman Opposes Schumer’s Zyn Nicotine Pouch Crackdown For Same ‘Freedom’ Reasons He Backs Marijuana Legalization

Sen. John Fetterman (D-PA) says he doesn’t support Senate Majority Leader Chuck Schumer’s (D-NY) call for a crackdown on the nicotine product Zyn because it’s a matter of “freedom and personal choices,” drawing parallels to his reasons for supporting marijuana…
Read
Random Post

States to Start Reversing Marijuana Legalization? - Montana Bill Would Tear Down Recreational Cannabis Market

In a move that could severely impact Montana's budding cannabis industry, Republican Senator Keith Regier has presented a bill that would effectively dismantle the state's recreational sales program just over a year after its launch. The proposed legislation, Senate Bill…
Read
Random Post

Study: Teen Binge Drinking Declined Following Adult-Use Cannabis Legalization

A recent study suggests a decline in teen binge drinking follows the passage of adult-use cannabis laws, but researchers also noted an increase in binge drinking among adults 31 and older. The study, “Recreational cannabis legislation and binge drinking in U.S. adolescents…
Read
Random Post

Texas Activists Turn In Signatures To Put Marijuana Decriminalization Back In Voters’ Hands After City Council Repeal

Texas activists have turned in what they say are enough signatures to place a measure on the Harker Heights ballot to reverse a City Council move that repealed a voter-approved marijuana decriminalization initiative. Ground Game Texas, which was behind a…
Read